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Resources for tackling COVID-19 in Oncology

30 April 2020

A table of COVID-19 oncology resources previously published may be found HERE. This table will be regularly updated.

 

Latest News and Resources

 

1. Macmillan Cancer Support – Information for patients

Since the COVID-19 pandemic there has been a clear reduction in the number of patients being referred into hospitals for urgent investigation for potential cancers. Macmillan are seeking to encourage the public to present to their GPs with symptoms of cancer and reassure them that cancer tests can be carried out safely.   Your GP is still here for you link to you tube https://www.youtube.com/watch?v=O7JDiuEG15c&feature=youtu.be

2. Government Guidance

Coronavirus (COVID-19): latest guidance for medicines safety – This lists key MHRA advice and guidance issued so far on medicines safety and pharmacovigilance, including on reporting to the Yellow Card Scheme.

Available at: https://www.gov.uk/drug-safety-update/coronavirus-covid-19-latest-guidance-for-medicines-safety

NHS England Clinical guide for the management of palliative care in hospital during the coronavirus pandemic (last updated 22.4.20) available at:  https://www.england.nhs.uk/coronavirus/wp-content/uploads/sites/52/2020/04/C0081-AMENDED-Speciality-guide-Palliative-care-and-coronavirus-v2-2020-04-22.pdf

COVID-19: guidance for stepdown of infection control precautions within hospitals and discharging COVID-19 patients from hospital to home settings - Advice on appropriate infection prevention and control (IPC) precautions for stepdown in hospital or discharge to home or residential settings. (23.4.2020) Available at: https://www.gov.uk/government/publications/covid-19-guidance-for-stepdown-of-infection-control-precautions-within-hospitals-and-discharging-covid-19-patients-from-hospital-to-home-settings

New guarantee on death in service benefits for frontline health and care staff during pandemic (27.4.20) - The families of health and care workers on the frontline in England will benefit from a new life assurance scheme during the coronavirus (COVID-19) pandemic. Available at: https://www.gov.uk/government/news/new-guarantee-on-death-in-service-benefits-for-frontline-health-and-care-staff-during-pandemic?utm_source=79e7d581-5fa0-4c0b-8073-27bc6b7deef4&utm_medium=email&utm_campaign=govuk-notifications&utm_content=daily

 Covid-19: What do we know so far about a vaccine?

The World Health Organization has announced that 83 potential covid-19 candidate vaccines are being assessed (as at 23 April), including seven that have now been approved for human testing through clinical trials. The MHRA has approved a COVID-19 vaccine trial to start in Oxford. Available at: https://www.gov.uk/government/news/mhra-approves-covid-19-vaccine-trial-in-7-working-days

Management of patients with multiple myeloma during the COVID-19 pandemic

Review summarises some recommendations to help with management of these patients. Authors’ state data regarding patients with haematological malignancies are scarce. Nevertheless, the SARS-CoV-2 infection pattern is expected to be similar to that of patients with solid cancers. https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(20)30124-1/fulltext  

 

An evidence summary of paediatric literature around COVID. This post is a rapid literature review of pertinent paediatric literature regarding COVID-19 disease. We are proud to have joined forces with the UK Royal College of Paediatrics and Child Health to provide systematic search, and selected reviews of all the COVID-19 literature relevant to children and young people. https://dontforgetthebubbles.com/evidence-summary-paediatric-covid-19-literature/

Mobile coronavirus testing units to target frontline workers Mobile testing units, operated by the Armed Forces, will travel around the UK to increase access to coronavirus testing. Available at: https://www.gov.uk/government/news/mobile-coronavirus-testing-units-to-target-frontline-workers?utm_source=5e624210-bb20-4a50-8c5f-5ab3c1ee664b&utm_medium=email&utm_campaign=govuk-notifications&utm_content=daily

Weekly COVID-19 surveillance report published PHE will be publishing a new weekly COVID-19 epidemiology surveillance summary. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/880925/COVID19_Epidemiological_Summary_w17.pdf

Latest from eCancer.org on CoVid19 this is a link to the latest available evidence from eCancer. available at: https://ecancer.org/en/news/17527-covid-19-resources       

3. NICE Guidance

COVID-19 rapid guideline: critical care in adults (updated 24.4.20) - They clarified the role of specialists in their recommendation on frailty assessment. Available at: https://www.nice.org.uk/guidance/ng159

COVID-19 rapid guideline: managing symptoms (including at the end of life) in the community Last updated: 22 April 2020 updated guidance on the use of ibuprofen as an antipyretic. Available at: https://www.nice.org.uk/guidance/ng163/chapter/Update-information 

4. Research articles

28/04/2020 update

  • Nekhlyudov, L., Duijts, S., Hudson, S.V. et al. Addressing the needs of cancer survivors during the COVID-19 pandemic. J Cancer Surviv (2020). https://doi.org/10.1007/s11764-020-00884-w 
  • He, W., Chen, L., Chen, L., Yuan, G., Fang, Y., Chen, W., & Li, L. (2020). COVID-19 in persons with haematological cancers. Leukemia, epub, https://doi.org/10.1038/s41375-020-0836-7 
  • Sud, A., Jones, M. E., Broggio, J., Loveday, C., Torr, B., Garrett, A., & Handy, J. M. (2020). Collateral damage: the impact on cancer outcomes of the COVID-19 pandemic. PREPRINT medRxiv. https://www.medrxiv.org/content/10.1101/2020.04.21.20073833v1
  • Saini, K. S., de las Heras, B., de Castro, J., Venkitaraman, R., Poelman, M., Srinivasan, G., ... & Curigliano, G. (2020). Effect of the COVID-19 pandemic on cancer treatment and research. The Lancet Haematology. https://doi.org/10.1016/S2352-3026(20)30123-X 
  • Barbieri, L., Talavera Urquijo, E., Parise, P., Nilsson, M., Reynolds, J. V., & Rosati, R. (2020). Esophageal oncologic surgery in SARS-CoV-2 (COVID-19) emergency. Diseases of the Esophagus. https://doi.org/10.1093/dote/doaa028 
  • Ardura, M. I., Hartley, D. M., Dandoy, C., Lehmann, L., Jaglowski, S., & Auletta, J. J. (2020). Addressing the impact of the Coronavirus Disease (COVID-19) pandemic on hematopoietic cell transplantation: Learning networks as means for sharing best practices. Biology of Blood and Marrow Transplantation. https://www.bbmt.org/article/S1083-8791(20)30229-9/pdf 
  • Dietz JR, Moran MS, Isakoff SJ, et al. Recommendations for prioritization, treatment, and triage of breast cancer patients during the COVID-19 pandemic. the COVID-19 pandemic breast cancer consortium [2020 Apr 24]. Breast Cancer Res Treat. http://doi.org/10.1007/s10549-020-05644-z 

5. Times Higher Education (THE) Some types of patient data, crucial for understanding who might be worst hit by the virus, are often inaccessible for researchers. A new portal hopes to change that by centralising the European data. https://www.timeshighereducation.com/news/europe-seeks-centralise-fractured-coronavirus-data?utm_source=THE+Website+Users&utm_campaign=a9f9eb90f5-EMAIL_CAMPAIGN_2020_04_24_02_50&utm_medium=email&utm_term=0_daa7e51487-a9f9eb90f5-74749477

6. The Royal Society of Medicine RSM Live brings together leading experts and decision makers to share, discuss and debate the latest developments on a range of healthcare topics and specialties. There are a range of webinars available for free on this website around CoVid19. Available at: https://www.rsm.ac.uk/rsmlive

7. NHSE Guidance on reuse of medicines in care homes and hospices during COVID-19 https://www.gov.uk/government/publications/coronavirus-covid-19-reuse-of-medicines-in-a-care-home-or-hospice

8. Updated resources on Macmillan learnzone On the Learnzone the palliative, end of life care and prehabilitation resources have updates https://learnzone.org.uk/coronavirus/. On the Coronavirus hub The End of Life page is now updated with all of the information about funerals: https://www.macmillan.org.uk/coronavirus/end-of-life-care-and-coronavirus. The treatment videos have been added to the treatment page. They are really  helpful, reassuring, and have real human content, with thanks to everyone who made these happen! https://www.macmillan.org.uk/coronavirus/cancer-treatment-and-coronavirus

9. Blood cancer UK survey of 3000 people on COVID-19 experience

Blood Cancer UK surveyed more than 3,000 people affected by blood cancer to find out their concerns about coronavirus. The results and proposed actions are published here  https://bloodcancer.org.uk/news/findings-our-survey-covid-19/

10. Prescribing Advice in COVID-19 Disease

a) MHRA Drug Safety Update- Coronavirus (COVID-19): latest guidance for medicines safety

Key MHRA advice and guidance issued so far on medicines safety and pharmacovigilance, including on reporting to the Yellow Card Scheme is available here https://www.gov.uk/drug-safety-update/coronavirus-covid-19-latest-guidance-for-medicines-safety

b) Offer of free access to online training for prescribing

CHAIN is a successful online mutual support network of people working in health and social care. The Network originated 20 years ago in the NHS Research & Development programme in England. They have produced a training resource for prescribers, which has just been made freely available due to the current COVID-19 pandemic. It is available here https://www.safemedicate.com/sm_site/promo/nhsoffer.php

 

11. SafeFit: Virtual clinics to deliver universal interventions to maintain and improve mental and physical health in people with cancer who are following social distancing guidance: A COVID-19 targeted trial


A recent statement by Professor Chris Whitty, Chief Medical Officer, NHS England, emphasised the significant benefits of exercise for all people. He said -:
 “this may be challenging for people self-isolating and even more so for those highly vulnerable people that are having to shield against the virus within their own home”. 


SafeFit has been designed, in response to the COVID-19 crisis, to support people living with cancer to maintain and improve their physical and mental health and well-being, whilst following government guidelines. 


The service is for people living with cancer aged 18 years and over who will access the service via a dedicated page on the Macmillan website. The service will be delivered by CanRehab specialist exercise instructors, who will undertake a robust screening and holistic needs assessment.   


People will be supported remotely in their own homes with advice about exercise, nutrition and emotional support - the ‘universal interventions’ described in the Principles and Guidance for Prehabilitation in the support and management of people with cancer (https://www.macmillan.org.uk/about-us/health-professionals/resources/practical-tools-forprofessionals/prehabilitation.html), the NHS England Personalised Care model and aligns to the development and inclusion of prehabilitation in national cancer strategies in Northern Ireland, Scotland and Wales.


An integral part of this service will be a COVID-19 interventional evaluation trial led by the University Hospitals Southampton NHS Trust WesFit research team. This will provide the evidence required by commissioners and include both primary and secondary outcomes.


The service interventions will be delivered by one of more of the following methods: 
• individual telephone consultations 
• one to one video exercise sessions 
• group exercise sessions. 


People living with cancer are likely to need different numbers of interventions and this will be accommodated as part of this developing service offer.
The instructors will have information required to enable them to signpost people to both Macmillan and other local information and service offers based on their identified needs including ‘Move More’ services in Northern Ireland and Scotland.


The service, due to go live imminently, has been set up initially for a six -month period during which there will be close monitoring of the demand, capacity and funding options for the service going forward. 


The ambition is that SafeFit will become a business as usual service, providing on-going support for people affected by cancer, especially during the extremely challenging recovery period of this pandemic. This model is highly translatable and transferable to all people with chronic diseases, particularly those recovering from critical illness


SafeFit has been developed in partnership with:  University Hospitals Southampton NHS Trust,  Wessex Cancer Alliance, Macmillan Cancer Support, CanRehab Trust

 

  • Covid-19 treatments could be fast tracked through new national clinical trial initiative

This will accelerate the development of new drugs for patients hospitalised with COVID-19, reducing the time taken to set up clinical studies for new therapies from months to weeks. Click here to access: https://www.gov.uk/government/news/covid-19-treatments-could-be-fast-tracked-through-new-national-clinical-trial-initiative?utm_source=cfe12fba-ccf3-4b34-a54b-858f4733d771&utm_medium=email&utm_campaign=govuk-notifications&utm_content=daily

  • Current awareness service for health 

Links and Resources to provide easy access to the key sources of information about the pandemic. Click here to access: http://cash.libraryservices.nhs.uk/subject-a-z/i/infection-prevention-and-control/covid-19/

  • COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital

NICE guidance available here: https://www.nice.org.uk/guidance/ng173